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Literature summary for 6.2.1.64 extracted from

  • Walden, H.; Podgorski, M.; Schulman, B.
    Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8 (2003), Nature, 422, 330-334 .
    View publication on PubMed
Search for more literature for 6.2.1.64

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine Homo sapiens
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 AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine
-
 Homo sapiens AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine
-
 ?
additional information first, the enzyme associates with the Ublp and catalyses adenylation of the carboxy terminus of the ubiquitin-like protein. Second, the enzyme forms a thioester between its catalytic cysteine and the ubiquitin-like protein. Next, the enzyme is loaded with a second ubiquitin-like protein molecule, adenylating the C terminus of this second ubiquitin-like protein while still carrying the first thioester-bound ubiquitin-like protein. Last, the enzyme binds E2 and promotes ubiquitin-like protein transfer to the catalytic cysteine of E2 enzyme Homo sapiens ?
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-

Subunits

Subunits Comment Organism
heterodimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
activating enzyme for NEDD8
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 Homo sapiens
APPBP1-UBA3
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 Homo sapiens
E1 enzyme for NEDD8
-
 Homo sapiens